Endocrine Abstracts

Introduction: Polycystic ovary syndrome (PCOS) is the most common endocrine pathology in premenopausal women and it is a complex syndrome affecting various systems. Numerous studies have been made about how the PCOS effects on bone metabolism, but currently there is no clear information. Wnt pathway plays important role in the regulation of bone metabolism. The sclerostin(Scl) and Dickkopf-1 (DKK1) inhibit this pathway and they has recently become a therapeutic target of osteo...

Background: There is some evidence suggesting an interaction between renin-angiotensin-aldosterone system and parathyroid hormone (PTH). Decreased aldosterone levels after parathyroidectomy have been reported in patients with primary hyperparathyroidism (PHPT). Recently, most of the diagnosed patients with PHPT are mild or asymptomatic. Our aim was to investigate plasma aldosterone and renin concentrations in patients with asymptomatic PHPT.Methods: Thir...

Background and aims: Neuropeptide Y (NPY) cause decrease glomerular filtration rate, aldosterone concentration, and plasma renin activity by stimulating NPY receptors in the kidney. Previous studies have suggested that NPY polymorphism is related to development of advanced diabetic nephropathy (DN). The aim of this study was to evaluate the relationship between the serum neuropeptide Y levels and different stages of DN in patients with type 2 diabetes mellitus (T2DM).<p cl...

Background and aims: Orexins are hypothalamic neuropeptides involved in energy homeostasis and sleep regulation. We aimed to find the relation between serum orexin-A levels, glucose, and insulin levels, depression and sleep problems in patients with metabolic syndrome.Materials and methods: This descriptive, cross-sectional study included 43 patients with metabolic syndrome (patient) and 16 healthy subjects (control, age, and sex matched) who applied to ...

Objective: Vitamin D deficiency has been shown to alter insulin synthesis and secretion in both humans and animal models. However, less is known on the association between vitamin D and type 2 diabetes mellitus. In the current study we aimed to analyze the relationship between vitamin D levels with glycemic control in type 2 diabetic patients.Material and methods: Three hundred and twenty diabetic patients who are follow up at least 6 months for diabetes...

Aim: In our study, we aimed to evaluate the relationship between oxidative stress markers such as total antioxidant capacity (TAC), advanced oxidant protein products (AOPP) and thiol-disulfide homeostasis parameters and diabetic peripheral neuropathy (PNP), an important microvascular complication of diabetes mellitus (DM).Material and methods: 80 (male/female=34/46) patients with type 2 DM and 19 healthy controls were included in the stu...

Endocan has been suggested as a marker for endothelial dysfunction. Some evidence exists that Graves’ disease may be associated with impaired endothelial function. The aim of the study was to evaluate serum endocan, endothelial growth factor (VEGF) and carotid intima media thickness (CIMT) in patients with Graves’ disease. Thirty one newly diagnosed patients with Graves’ disease and 31 healthy volunteers with similar age and sex were examined. Serum endocan, VEG...

IntroductionLangerhans cell histiocytosis (LCH) is a rare monoclonal disease characterized by abnormal proliferation and accumulation of bone marrow-derived Langerhans cells in various tissues. Heterogeneous collections of Langerhans cells with neutrophils, lymphocytes, eosinophils, histiocytes and Birbeck granules are observed in biopsy materials. Endocrinologic features of LCH are usually due to posterior pituitary involvement. Thyroid infiltration is ...

Hyperthyroidism whether endogenous or exogenous in origin causes hemodynamic changes which associated with adverse cardiovascular outcomes. Ambulatory arterial Stiffness index (AASI) is a non invasive way of measuring arterial stiffness. Short term BP variability is derived from 24-hour ambulatory blood pressure monitoring (ABPM) recordings. BP variability and AASI are associtaed with increased cardiovascular risk.We aimed to investigate AASI and short t...

Idiopathic granulomatous hypophysitis is a very rare inflammatory disease of the pituitary gland. Primary hypophysitis represents a difficult diagnostic challenge because it can imitate pituitary adenomas clinically and radiologically. The diagnosis is usually made histologically by hypophysectomy. We herein present a rare case of idiopathic granulomatous hypopysitis diagnosed primarily by pituitary biopsy.Case: A 50-year-old female patient presented wit...